B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus

Chao, Brittany, Frederico, Bruno and Stevenson, Philip G. (2015) B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus. Journal of General Virology, 96 9: 2788-2793. doi:10.1099/vir.0.000188


Author Chao, Brittany
Frederico, Bruno
Stevenson, Philip G.
Title B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 1465-2099
0022-1317
Publication date 2015-09-01
Year available 2015
Sub-type Article (original research)
DOI 10.1099/vir.0.000188
Open Access Status Not Open Access
Volume 96
Issue 9
Start page 2788
End page 2793
Total pages 6
Place of publication Reading, Berks United Kingdom
Publisher Society for General Microbiology
Collection year 2016
Language eng
Abstract Lymphocytes provide gammaherpesviruses with a self-renewing substrate for persistent infection and with transport to mucosal sites for host exit. Their role in the initial colonization of new hosts is less clear. Murid herpesvirus 4 (MuHV-4), an experimentally accessible, B-cell-tropic rhadinovirus (gamma-2 herpesvirus), persistently infects both immunocompetent and B-cell-deficient mice. A lack of B-cells did not compromise MuHV-4 entry into lymphoid tissue, which involved myeloid cell infection. However, it impaired infection amplification and MuHV-4 exit from lymphoid tissue, which involved myeloid to B-cell transfer.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Clinical Medical Virology Centre Publications
 
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