Infectious agents in mucosa-associated lymphoid tissue-type lymphomas: pathogenic role and therapeutic perspectives

Guidoboni, Massimo, Ferreri, Andrés J. M., Ponzoni, Maurilio, Doglioni, Claudio and Dolcetti, Riccardo (2006) Infectious agents in mucosa-associated lymphoid tissue-type lymphomas: pathogenic role and therapeutic perspectives. Clinical Lymphoma and Myeloma, 6 4: 289-300. doi:10.3816/CLM.2006.n.003


Author Guidoboni, Massimo
Ferreri, Andrés J. M.
Ponzoni, Maurilio
Doglioni, Claudio
Dolcetti, Riccardo
Title Infectious agents in mucosa-associated lymphoid tissue-type lymphomas: pathogenic role and therapeutic perspectives
Journal name Clinical Lymphoma and Myeloma   Check publisher's open access policy
ISSN 1557-9190
2152-2669
Publication date 2006-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3816/CLM.2006.n.003
Open Access Status Not yet assessed
Volume 6
Issue 4
Start page 289
End page 300
Total pages 12
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Formatted abstract
Mucosa-associated lymphoid tissue (MALT) lymphoma probably constitutes the best in vivo model showing how complex interplay between B lymphocytes and the surrounding microenvironment may lead to a neoplastic disorder. After the seminal discovery of the pathogenic association between Helicobacter pylori and gastric MALT lymphomas, evidence suggests the possible involvement of other infectious agents in the development of MALT lymphomas arising at different body sites. Although several other bacteria (Borrelia burgdorferi, Campylobacter jejuni, and Chlamydia psittaci) and viruses (Hepatitis C virus) seem to play a role in lymphomas presenting at different locations, a possible common pathogenic mechanism is emerging. Several lines of evidence suggest that different infectious agents might provide a chronic antigenic stimulation that elicits host immune responses able to promote clonal B-cell expansion. This model is also substantiated by the increasing number of patients with MALT lymphomas who exhibit objective clinical responses after antimicrobial therapy. A multidisciplinary approach is critical to better understand the complex etiopathogenesis of MALT lymphomas with the final goal to dissect the clinicopathologic heterogeneity of these disorders and design more tailored preventive and therapeutic approaches.
Keyword Borrelia burgdorferi
Campylobacter jejuni
Chlamydia psittaci
Helicobacter pylori
Hepatitis C virus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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