Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer

Martorelli, Debora, Muraro, Elena, Merlo, Anna, Turrini, Riccardo, Rosato, Antonio and Dolcetti, Riccardo (2010) Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer. International Reviews of Immunology, 29 4: 371-402. doi:10.3109/08830185.2010.489658


Author Martorelli, Debora
Muraro, Elena
Merlo, Anna
Turrini, Riccardo
Rosato, Antonio
Dolcetti, Riccardo
Title Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer
Formatted title
Role of CD4 cytotoxic T lymphocytes in the control of viral diseases and cancer
Journal name International Reviews of Immunology   Check publisher's open access policy
ISSN 0883-0185
1563-5244
1026-8006
Publication date 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/08830185.2010.489658
Open Access Status Not Open Access
Volume 29
Issue 4
Start page 371
End page 402
Total pages 32
Place of publication Abingdon, Oxfordshire United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Our knowledge on the physiological role of CD4+ T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the ‘helper’ activity, CD4+ T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD4+ T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4+ T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders.
Keyword Cytotoxicity
CD4+ T cells
Epstein-Barr virus
Cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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