Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: Clinical and therapeutic implications

Ferreri, AJ, Ponzoni, M, Viale, E, Guidoboni, M, De Conciliis, C, Resti, AG, Politi, L, Lettini, AA, Sacchetti, F, Dognini, G, Dolcetti, R and Doglioni, C (2006). Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: Clinical and therapeutic implications. In: 9th International Conference on Malignant Lymphoma, Lugano Switzerland, (33-37). Jun 09-11, 2005. doi:10.1002/hon.768


Author Ferreri, AJ
Ponzoni, M
Viale, E
Guidoboni, M
De Conciliis, C
Resti, AG
Politi, L
Lettini, AA
Sacchetti, F
Dognini, G
Dolcetti, R
Doglioni, C
Title of paper Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: Clinical and therapeutic implications
Conference name 9th International Conference on Malignant Lymphoma
Conference location Lugano Switzerland
Conference dates Jun 09-11, 2005
Journal name Hematological Oncology   Check publisher's open access policy
Publication Year 2006
Sub-type Fully published paper
DOI 10.1002/hon.768
ISSN 0278-0232
Volume 24
Issue 1
Start page 33
End page 37
Total pages 5
Language eng
Abstract/Summary Background: The prevalence and the clinical impact of gastric Helicobacter pylori (Hp) infection, as well as its possible correlation with Chlamydia psittaci (Cps) infection and the lymphoma regression rate produced by Hp eradicating antibiotic therapy were investigated in patients with MALT-type lymphoma of the ocular adnexa (OAL). Methods: During staging, the presence of gastric Hp infection was assessed by gastroscopy and multiple biopsies in 31 OAL patients. Immediately after, Hp-positive patients were treated with eradicating antibiotic therapy, alone or associated with other therapies. Results: Gastric Hp infection was detected in 10 (32%) patients; this feature did not correlate with patients' characteristics and disease. Four Hp-positive patients were treated with Hp-eradicating antibiotics therapy as exclusive strategy (assessable for response), none of them showed lymphoma regression. Conversely, 6 Hp-positive patients were treated with antibiotic therapy concurrently with other therapies, achieving lymphoma regression in all cases. Three Hp-positive patients with Cps-positive lymphoma were treated with doxycycline at relapse, resulting in two CR and one PR, which lasted 24+, 20+, and 18+ months, respectively. One of these patients achieved a CR after doxycycline despite the chronic persistence of Hp infection, whereas Cps-eradication was confirmed in the analysis of PBMC samples. Conclusions: Gastric Hp infection, even if common among OAL patients, does not influence clinical presentation, Hp-eradicating antibiotic therapy is not active against OAL. Cps-eradicating antibiotic therapy with doxycycline induces lymphoma remission irrespectively of the persistence of Hp infection. Copyright
Subjects 2720 Hematology
2730 Oncology
1306 Cancer Research
Keyword Chlamydia psittaci
Helicobacter pylori
Infectious agents
MALT lymphoma
Ocular adnexal lymphoma
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
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