Genotypic and immunohistological demonstration of the progression of an unusual reactive-like B-cell lymphoproliferative disorder to a high grade diffuse lymphoma

Dolcetti, R, DE Re, V, Carbone, A, Devita, S, Gloghini, A, Tirelli, U, Pasquotti, B and Boiocchi, M (1995) Genotypic and immunohistological demonstration of the progression of an unusual reactive-like B-cell lymphoproliferative disorder to a high grade diffuse lymphoma. Human Pathology, 26 3: 348-354. doi:10.1016/0046-8177(95)90070-5


Author Dolcetti, R
DE Re, V
Carbone, A
Devita, S
Gloghini, A
Tirelli, U
Pasquotti, B
Boiocchi, M
Title Genotypic and immunohistological demonstration of the progression of an unusual reactive-like B-cell lymphoproliferative disorder to a high grade diffuse lymphoma
Journal name Human Pathology   Check publisher's open access policy
ISSN 0046-8177
Publication date 1995
Sub-type Article (original research)
DOI 10.1016/0046-8177(95)90070-5
Volume 26
Issue 3
Start page 348
End page 354
Total pages 7
Language eng
Subject 2734 Pathology and Forensic Medicine
Abstract In the present study the clinical and pathological evolution of a reactive-like B-cell lymphoproliferative disorder with an unusually high content of T cells is described. Immunogenotypic analysis showed that the same phenotypically atypical B-cell clone, characterized by the unusual presence of an immunoglobulin (Ig)K gene rearrangement, with the heavy chain (IgH) gene in germline configuration, was invariantly present in all phases of the disease. The disorder showed an indolent course for a long period of time during which the clonal B-cell population coexisted with an abundant, reactive T-cell component in different locations of the disease. These findings, together with the observation of spontaneous progression and regression phases of the disorder and its responsiveness to corticosteroids, suggest that functional interactions between the B-cell clone and the polyclonal infiltrating T cells probably were involved in the pathogenesis of the disease. After the administration of the antiblastic treatment, a progressive reduction of the reactive T-cell component was observed with the concomitant evolution to a diffuse large cell (immunoblastic) B-cell lymphoma and the appearance of an IgH gene rearrangement. The biological characteristics and the clinical evolution of the case described here are similar to those reported for the so-called "T-cell-rich B-cell lymphomas" (TCRBCLs). These findings suggest that the Tcell-rich pattern may identify a group of B-cell lymphoproliferations with common pathogenetic mechanisms and clinical behavior.
Keyword immunoglobulin gene rearrangement
in situ immunophenotyping
reactive T cells
T-cell-rich B-cell lymphoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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