High prevalence of Chlamydophila psittaci subclinical infection in Italian patients with Sjogren's syndrome and parotid gland marginal zone B-cell lymphoma of MALT-type

Fabris, M., Dolcetti, R., Pasini, E., Quartuccio, L., Pontarini, E., Salvin, S., Ponzoni, M., Scott, C. A. and De Vita, S. (2014) High prevalence of Chlamydophila psittaci subclinical infection in Italian patients with Sjogren's syndrome and parotid gland marginal zone B-cell lymphoma of MALT-type. Clinical and Experimental Rheumatology, 32 1: 61-65.

Author Fabris, M.
Dolcetti, R.
Pasini, E.
Quartuccio, L.
Pontarini, E.
Salvin, S.
Ponzoni, M.
Scott, C. A.
De Vita, S.
Title High prevalence of Chlamydophila psittaci subclinical infection in Italian patients with Sjogren's syndrome and parotid gland marginal zone B-cell lymphoma of MALT-type
Journal name Clinical and Experimental Rheumatology   Check publisher's open access policy
ISSN 0392-856X
1593-098X
Publication date 2014-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 32
Issue 1
Start page 61
End page 65
Total pages 5
Place of publication Ospedaletto, Italy
Publisher Pacini Editore SpA
Language eng
Formatted abstract
Objectives:  To assess Chlamydophila psittaci (Cp) subclinical infection in patients with Sjögren`s syndrome (SS).

Methods:  Seventy-four SS patients (55.4 ±13.4 yrs; 94.6% females) were studied. Among them, 18 had salivary gland mucosa-associated lymphoid tissue (MALT) B-cell lymphoma, 20 myoepithelial sialoadenitis (MESA), and 36 no lymphoproliferative disorders (LPD). The presence of Cp DNA was assessed in peripheral blood of all patients by specific PCR protocols. Paired salivary gland samples were also investigated whenever available (34 cases), including lymphomatous and non-lymphomatous samples, as well as major and minor salivary gland tissues. As controls, 225 blood donors were analysed in the peripheral blood.

Results:  Overall, Cp DNA was detected in 11/74 (14.9%) SS patients vs. 1/225 (0.4%) controls (p<0.0001). Cp was detected at higher frequency in MALT lymphoma patients (6/18, 33.3%), as compared with MESA (3/20, 15%) or patients without LPD (2/36, 5.6%), (MALT lymphomas vs. others: p=0.02). A similar Cp prevalence was observed in blood vs. salivary gland tissues, however with a higher frequency in the major than in the minor salivary glands (5/18, 27.8%, vs. 1/17, 5.9%, p=0.18). Cp-positive patients were all rheumatoid factor positive (11/11, 100% vs. 40/63, 63.5% Cp-negative; p=0.014), while no difference was noticed for anti-SSA/SSB positivity.

Conclusions:  In the light of accepted models of MALT B-cell lymphomagenesis and considering previous data implicating Cp infection in ocular adnexa MALT lymphoma, our results suggest that Cp infection could be involved also in a fraction of patients with SS developing lymphoma. The potential therapeutic implications of these findings appear worthwhile.
Keyword Sjogren's syndrome
MALT lymphoma
Infection
Chlamydophila psittaci
lymphomagenesis
Ocular Adnexal Lymphomas
Chlamydia-Psittaci
Association
Lymphoproliferation
Manifestations
Classification
Perspectives
Pneumoniae
Samples
Women
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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