Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy

Ferreri, A. J. M., Dolcetti, R., Du, M. -Q., Doglioni, C., Resti, A. Giordano, Politi, L. S., De Conciliis, C., Radford, J., Bertoni, F., Zucca, E., Cavalli, F. and Ponzoni, M. (2008) Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy. Annals of Oncology, 19 5: 835-846. doi:10.1093/annonc/mdm513


Author Ferreri, A. J. M.
Dolcetti, R.
Du, M. -Q.
Doglioni, C.
Resti, A. Giordano
Politi, L. S.
De Conciliis, C.
Radford, J.
Bertoni, F.
Zucca, E.
Cavalli, F.
Ponzoni, M.
Title Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy
Journal name Annals of Oncology   Check publisher's open access policy
ISSN 0923-7534
1569-8041
Publication date 2008-05
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/annonc/mdm513
Open Access Status Not yet assessed
Volume 19
Issue 5
Start page 835
End page 846
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Non-Hodgkin's lymphomas constitute one half of malignancies arising in the orbit and the ocular adnexae. Mucosa-associated lymphoid tissue (MALT)-type lymphoma is the most common histological category in this anatomic region. The incidence of ocular adnexal lymphoma of mucosa-associated lymphoid tissue-type (OAML) is increasing and recent studies offered new relevant insights in molecular, pathogenetic and therapeutic issues on these neoplasms. A pathogenetic model of antigen-driven lymphoproliferation similar to that reported for Helicobacter pylori-related gastric MALT lymphomas has been hypothesized for OAML. This notion is supported by the association between OAML and Chlamydophila psittaci infection, an association that is of likely pathogenetic relevance and may influence both the biological behavior and the therapeutic management of these neoplasms. However, this association displays evident geographical variability indicating that other etiopathogenic agents could be involved. These recent acquisitions coupled with the occurrence of chromosomal translocations and other genetic alterations, as well as additional risk factors like autoimmune disorders have contributed to render OAML an exciting challenge for a broad group of physicians and scientists. OAML is an indolent and rarely lethal malignancy that, in selected patients, can be managed with observation alone. Lymphomatous lesions are frequently responsible for symptoms affecting patient's quality of life, requiring, therefore, immediate treatment. Several therapeutic strategies are available, often associated with relevant side-effects. However, the therapeutic choice in OAML is not supported by consolidated evidence due to the lack of prospective trials. In this review, we analyze the most relevant biological, molecular, pathological and clinical features of OAML and propose some therapeutic guidelines for patients affected by this malignancy.
Keyword Chlamydia
Extranodal lymphomas
Interferon
MALT
Ocular adnexae
Rituximab
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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