Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications

Dolcetti, Riccardo and De Rossi, Anita (2012) Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications. Medicinal Research Reviews, 32 2: 233-253. doi:10.1002/med.20211


Author Dolcetti, Riccardo
De Rossi, Anita
Title Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications
Journal name Medicinal Research Reviews   Check publisher's open access policy
ISSN 0198-6325
1098-1128
Publication date 2012-03
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/med.20211
Open Access Status Not yet assessed
Volume 32
Issue 2
Start page 233
End page 253
Total pages 21
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Telomerase is a ribonucleoprotein complex critically involved in extending and maintaining telomeres. Unlike the majority of somatic cells, in which hTERT and telomerase activity are generally silent, normal lymphocytes show transient physiological hTERT expression and telomerase activity according to their differentiation/activation status. During lymphomagenesis, induction of persistent telomerase expression and activity may occur before or after telomere shortening, as a consequence of the different mechanisms through which transforming factors/agents may activate telomerase. Available data indicate that the timing of telomerase activation may allow the distinction of two different lymphomagenetic models: (i) an early activation of telomerase via exogenous regulators of hTERT, along with an increased lymphocyte growth and a subsequent selection of cells with increased transforming potential may characterize several virus-related lymphoid malignancies; (ii) a progressive shortening of telomeres, leading to genetic instability which favors a subsequent activation of telomerase via endogenous regulators may occur in most virus-unrelated lymphoid tumors. These models may have clinically relevant implications, particularly for the tailoring of therapeutic strategies targeting telomerase.
Keyword Telomerase
Telomerase inhibitors
Telomere length
Virus-driven lymphomagenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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