Lymphomas occurring specifically in HIV-infected patients: from pathogenesis to pathology

Gloghini, Annunziata, Dolcetti, Riccardo and Carbone, Antonino (2013) Lymphomas occurring specifically in HIV-infected patients: from pathogenesis to pathology. Seminars in Cancer Biology, 23 6 PA: 457-467. doi:10.1016/j.semcancer.2013.08.004


Author Gloghini, Annunziata
Dolcetti, Riccardo
Carbone, Antonino
Title Lymphomas occurring specifically in HIV-infected patients: from pathogenesis to pathology
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1044-579X
1096-3650
Publication date 2013-12
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcancer.2013.08.004
Open Access Status Not yet assessed
Volume 23
Issue 6 PA
Start page 457
End page 467
Total pages 11
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract Lymphomas that develop in HIV positive patients are predominantly aggressive B-cell malignancies. The most common HIV-associated lymphomas are Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Lymphomas that occur specifically in HIV positive patients include primary effusion lymphoma (PEL) and its solid variants, plasmablastic lymphoma of the oral cavity type and lymphoma associated with Kaposi sarcoma herpesvirus (KSHV)-related multicentric Castleman disease. These lymphomas, together with BL and immunoblastic lymphoma subtypes with plasmacytoid differentiation, carry Epstein-Barr virus (EBV) infection and display a phenotype related to plasma cells. Globally, EBV is identified in the neoplastic cells of approximately 40% of HIV-associated lymphomas, but the detection of EBV varies considerably with the site of presentation and the histological subtype. EBV infection occurs in 80-100% of primary central nervous system lymphomas and PELs, 80% of DLBCLs with immunoblastic-plasmacytoid features, and 30-50% of BL-plasmacytoid. KSHV is specifically associated with PEL, which usually occurs in a setting of profound immunosuppression. Current knowledge about HIV-associated lymphomas can be summarized as follows: (1) lymphomas specifically occurring in patients with HIV infection are closely linked to other viral diseases; (2) most of these lymphomas exhibit plasmablastic differentiation.
Keyword EBV
HIV-associated lymphomas
HIV-lymphoma
KSHV
Pathogenesis
Pathology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 49 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 27 Nov 2015, 19:35:18 EST by System User on behalf of Learning and Research Services (UQ Library)