Epstein-Barr virus: induction and control of cell transformation

Dolcetti, Riccardo and Masucci, Maria G. (2003) Epstein-Barr virus: induction and control of cell transformation. Journal of Cellular Physiology, 196 2: 207-218. doi:10.1002/jcp.10263


Author Dolcetti, Riccardo
Masucci, Maria G.
Title Epstein-Barr virus: induction and control of cell transformation
Journal name Journal of Cellular Physiology   Check publisher's open access policy
ISSN 0021-9541
1097-4652
Publication date 2003-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jcp.10263
Open Access Status Not yet assessed
Volume 196
Issue 2
Start page 207
End page 218
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Epstein-Barr virus (EBV), a ubiquitous human herpes virus, is associated with an increasing number of lymphoid and epithelial malignancies. The ability of the virus to establish life-long persistent infections and induce growth transformation is related to the function of a set of viral proteins that are variously expressed in both normal and malignant cells. Recent evidence indicates that these viral proteins are able to usurp cellular pathways that promote the cell growth and survival, while impairing anti-viral immune responses. Elucidation of the mechanisms by which EBV induces cell transformation and escapes host immune control provides the rational background for the design of new strategies of intervention for EBV-related malignancies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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