Interplay among viral antigens, cellular pathways and tumor microenvironment in the pathogenesis of EBV-driven lymphomas

Dolcetti, Riccardo, Dal Col, Jessica, Martorelli, Debora, Carbone, Antonino and Klein, Eva (2013) Interplay among viral antigens, cellular pathways and tumor microenvironment in the pathogenesis of EBV-driven lymphomas. Seminars in Cancer Biology, 23 6 PA: 441-456. doi:10.1016/j.semcancer.2013.07.005


Author Dolcetti, Riccardo
Dal Col, Jessica
Martorelli, Debora
Carbone, Antonino
Klein, Eva
Title Interplay among viral antigens, cellular pathways and tumor microenvironment in the pathogenesis of EBV-driven lymphomas
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1044-579X
1096-3650
Publication date 2013-12
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcancer.2013.07.005
Volume 23
Issue 6 PA
Start page 441
End page 456
Total pages 16
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract Epstein-Barr virus (EBV) is a ubiquitous human γ-herpes virus that has established an elegant strategy to persist as a life-long asymptomatic infection in memory B lymphocytes. EBV has potent transforming properties for B lymphocytes and it is pathogenically associated with a variety of lymphomas of B or NK/T cell origin. The viral latency programs expressed can hijack or deregulate cellular pathways critical for cell proliferation and survival, while impairing anti-viral immune responses. Similar effects may also be induced by EBV-encoded micro-RNAs, which may have a pathogenic role particularly in lymphomas showing a restricted expression of viral proteins. Of note, recent data have challenged the view that only the EBV latency is relevant for lymphomagenesis, suggesting that lytic EBV replication may also contribute to the development of EBV-associated lymphoproliferations. The recent advances in the elucidation of the mechanisms underlying EBV-induced cell transformation and immune evasion are providing the rationale for innovative and tailored treatment approaches for EBV-driven lymphomas.
Keyword Epstein-Barr virus
Latency
Lymphomas
Lytic replication
Signaling pathways
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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