Clinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with undifferentiated carcinoma of nasopharyngeal type

Bortolin, Maria Teresa, Pratesi, Chiara, Dolcetti, Riccardo, Bidoli, Ettore, Vaccher, Emanuela, Zanussi, Stefania, Tedeschi, Rosamaria and De Paoli, Paolo (2006) Clinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with undifferentiated carcinoma of nasopharyngeal type. Cancer Letters, 233 2: 247-254. doi:10.1016/j.canlet.2005.03.015


Author Bortolin, Maria Teresa
Pratesi, Chiara
Dolcetti, Riccardo
Bidoli, Ettore
Vaccher, Emanuela
Zanussi, Stefania
Tedeschi, Rosamaria
De Paoli, Paolo
Title Clinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with undifferentiated carcinoma of nasopharyngeal type
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
1872-7980
Publication date 2006-02-28
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.canlet.2005.03.015
Open Access Status Not yet assessed
Volume 233
Issue 2
Start page 247
End page 254
Total pages 8
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
We investigated EBV viremia in matched serum and peripheral blood mononuclear cells (PBMCs) from one of the largest Italian cohort of Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT) patients (N=34). By using a LMP-1 real-time PCR assay, we found that EBV DNA detection rate was 74% (median 8417 copies/ml) and 24% (median 164 copies/106 cells) on serum and PBMCs, respectively. Significantly higher serum EBV DNA levels were detected in patients with advanced UCNT (nodal stage N2 versus N0-1 and N3 versus N0-1, P=0.03 and 0.018; overall stage IV versus I-II, P=0.03). During the follow-up, there was also a statistically significant difference of EBV DNA viral load between patients with and without clinical relapse (P=0.008). We concluded that serum EBV DNA reflects the biological activity of the UCNT and may be a prognostic factor also in a low-incidence region.
Keyword Epstein-Barr virus
Real-time PCR
Undifferentiated carcinoma of nasopharyngeal type
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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