B lymphocytes and Epstein-Barr virus: the lesson of post-transplant lymphoproliferative disorders

Dolcetti, Riccardo (2007) B lymphocytes and Epstein-Barr virus: the lesson of post-transplant lymphoproliferative disorders. Autoimmunity Reviews, 7 2: 96-101. doi:10.1016/j.autrev.2007.02.012


Author Dolcetti, Riccardo
Title B lymphocytes and Epstein-Barr virus: the lesson of post-transplant lymphoproliferative disorders
Journal name Autoimmunity Reviews   Check publisher's open access policy
ISSN 1568-9972
1873-0183
Publication date 2007-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.autrev.2007.02.012
Open Access Status Not yet assessed
Volume 7
Issue 2
Start page 96
End page 101
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract Epstein-Barr virus (EBV) is a ubiquitous human γ-herpes virus that establishes a life-long asymptomatic infection in immunocompetent hosts by colonizing memory B lymphocytes and hijacking cellular signaling pathways that regulate antigen-dependent B-cell activation and differentiation. In patients with solid organ or hematopoietic stem cell transplantation, the defect in EBV-specific immune responses may allow the outgrowth of EBV-carrying B lymphocytes that may give rise to a spectrum of different clinico-pathologic entities encompassed by the term post-transplantation lymphoproliferative disorders (PTLD). EBV-driven immortalization of B-cells is mediated by the cooperative activity of viral proteins that derange critical cellular pathways controlling growth and/or survival of B lymphocytes. Full transformation of infected B-cells is achieved by the contribution of poorly defined additional co-factors, including microenvironmental stimuli, genetic and epigenetic alterations. The quantification of circulating EBV DNA and EBV-specific T cells are valuable tools in the clinical monitoring of EBV-associated PTLD. The recent advances in elucidation of the mechanisms underlying EBV-induced growth transformation will be instrumental in guiding the design of novel approaches for the treatment of these often life-threatening lymphoproliferative disorders.
Keyword B lymphocytes
Epstein-Barr virus
Post-transplantation lymphoproliferative disorders
Viral load
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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