Role of the HLA class II: HCV-related disorders

de Re, Valli, Caggiari, Laura, Simula, Maria Paola, de Vita, Salvatore, Mazzaro, Cesare, Lenzi, Marco, Massimo, Galli M., Monti, Giuseppe, Ferri, Clodoveo, Zignego, Anna Linda, Gabrielli, Armando, Sansonno, Domenico, Dammacco, Franco, Libra, Massimo, Sacchi, Nicoletta, Talamini, Renato, Spina, Michele, Tirelli, Umberto, Cannizzaro, Renato and Dolcetti, Riccardo (2007). Role of the HLA class II: HCV-related disorders. In: 5th International Congress on Autoimmunity, Sorrento Italy, (308-318). Nov 29-Dec 03, 2006. doi:10.1196/annals.1381.033


Author de Re, Valli
Caggiari, Laura
Simula, Maria Paola
de Vita, Salvatore
Mazzaro, Cesare
Lenzi, Marco
Massimo, Galli M.
Monti, Giuseppe
Ferri, Clodoveo
Zignego, Anna Linda
Gabrielli, Armando
Sansonno, Domenico
Dammacco, Franco
Libra, Massimo
Sacchi, Nicoletta
Talamini, Renato
Spina, Michele
Tirelli, Umberto
Cannizzaro, Renato
Dolcetti, Riccardo
Title of paper Role of the HLA class II: HCV-related disorders
Conference name 5th International Congress on Autoimmunity
Conference location Sorrento Italy
Conference dates Nov 29-Dec 03, 2006
Journal name Autoimmunity, Pt C   Check publisher's open access policy
Publication Year 2007
Sub-type Fully published paper
DOI 10.1196/annals.1381.033
ISBN 1573316628
ISSN 0077-8923
Volume 1107
Start page 308
End page 318
Total pages 11
Language eng
Abstract/Summary The paper highlights the role of different HLA class II molecules in hepatic and lymphoproliferative HCV-related disorders. HLA molecules have been reviewed, according to an in silico cluster classification, based on the sequence, the biochemical structure of the pockets, and the functional characteristics of the HLA II molecules. Thus, by reducing the complexity of HLA II polymorphism, charateristics that unite different HLA molecules with specific HCV-associated pathologies may be recognized with greater case. Results show that HLA clusters associated with better dlimination of the virus are protective against HCC development, while the same clusters are associated with a higher risk of developing cryoglobulinemic syndrome and the concomitant NHL. These data added further acknowledgements on pathogenetic mechanisms associated with HCV infection. Results also highlight differences of NHL occurring in HCV-positive subjects, with or without a concomitant type II autoimmune cryoglobulinemic syndrome, suggesting that cryoglobulinemic background associated with NHL should be considered in the evaluation of the effectiveness of new therapies in the course of HCV-associated NHLs.
Subjects 1300 Biochemistry, Genetics and Molecular Biology
Keyword B-cell lymphoproliferation
Cryoglobulinemia
Hepatitis C virus
Hepatocarcinoma
HLA DQB1
HLA DRB1
Lymphoma
MHC allele
SBT
Sequence-based typing
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
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Created: Fri, 27 Nov 2015, 19:17:33 EST by System User