A comparison of sperm DNA damage in the neat ejaculate of sperm donors and males presenting for their initial seminogram

Gosálvez, Jaime, Fernández, José-Luis, Yaniz, Jesus, de la Casa, Moises, López- Fernández, Carmen and Johnston, Stephen (2015) A comparison of sperm DNA damage in the neat ejaculate of sperm donors and males presenting for their initial seminogram. Austin Journal of Reproductive Medicine and Infertility, 2 3: 1014.1-1014.4.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Gosálvez, Jaime
Fernández, José-Luis
Yaniz, Jesus
de la Casa, Moises
López- Fernández, Carmen
Johnston, Stephen
Title A comparison of sperm DNA damage in the neat ejaculate of sperm donors and males presenting for their initial seminogram
Journal name Austin Journal of Reproductive Medicine and Infertility
Publication date 2015-06-29
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 2
Issue 3
Start page 1014.1
End page 1014.4
Total pages 4
Place of publication New Jersey, NY, United States
Publisher Austin Publications
Collection year 2016
Language eng
Formatted abstract
A standardised value for characterization of sperm DNA fragmentation (SDF) and fertility prediction in patients is regarded as controversial and is one of the primary reasons why the assessment of the sperm DNA is not commonly incorporated into the routine seminogram. To address this conundrum we have conducted an analysis of the incidence of sperm DNA damage between sperm donors and a random cohort of males requested for a first seminogram. The underlying assumption was that sperm DNA damage is a neutral sperm characteristic and differences would not be expected between both cohorts. We analyzed SDF using the sperm chromatin dispersion assay in two large cohorts of individuals that included a comparison of seminograms from 210 sperm donors and 775 couples presenting to the clinic for first time. Results of the analysis revealed that sperm DNA damage cannot be considered as neutral parameter between the two populations (Donor: SDF Mean = 10.7; SD: 8.7; First seminogram: Mean =29.2; SD: 17.6; U-Mann-Whitney 20486; P 0.000). Receiving operating characteristics curves constructed under the parameters of this study showed that a SDF value of 16% was able to discriminate both cohorts of individuals with a sensitivity of 85% and a specificity of 75%. We suggest that when clinics are selecting for sperm donors, they are also likely to be indirectly selecting for a level of SDF which is in the order of 20 points lower than the level found in those couples presenting to the clinic for the first time.
Keyword Andrology
Sperm DNA fragmentation
Male factor
Sperm donors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes http://austinpublishinggroup.com/reproductive-medicine/fulltext/ajrm-v2-id1014.php

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Agriculture and Food Sciences
 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Fri, 27 Nov 2015, 13:38:08 EST by Associate Professor Stephen Johnston on behalf of School of Agriculture and Food Sciences