Exercise improves quality of life in androgen deprivation therapy-treated prostate cancer: systematic review of randomised controlled trials

Teleni, Laisa, Chan, Raymond J., Chan, Alexandre, Isenring, Elisabeth A., Vela, Ian, Inder, Warrick J. and McCarthy, Alexandra L. (2016) Exercise improves quality of life in androgen deprivation therapy-treated prostate cancer: systematic review of randomised controlled trials. Endocrine-Related Cancer, 23 2: 101-112. doi:10.1530/ERC-15-0456


Author Teleni, Laisa
Chan, Raymond J.
Chan, Alexandre
Isenring, Elisabeth A.
Vela, Ian
Inder, Warrick J.
McCarthy, Alexandra L.
Title Exercise improves quality of life in androgen deprivation therapy-treated prostate cancer: systematic review of randomised controlled trials
Journal name Endocrine-Related Cancer   Check publisher's open access policy
ISSN 1351-0088
1479-6821
Publication date 2016-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.1530/ERC-15-0456
Open Access Status Not Open Access
Volume 23
Issue 2
Start page 101
End page 112
Total pages 12
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Collection year 2016
Language eng
Abstract Men receiving androgen deprivation therapy (ADT) for prostate cancer (PCa) are likely to develop metabolic conditions such as diabetes, cardiovascular disease, abdominal obesity and osteoporosis. Other treatment-related side effects adversely influence quality of life (QoL) including vasomotor distress, depression, anxiety, mood swings, poor sleep quality and compromised sexual function. The objective of this study was to systematically review the nature and effects of dietary and exercise interventions on QoL, androgen deprivation symptoms and metabolic risk factors in men with PCa undergoing ADT. An electronic search of CINAHL, CENTRAL, Medline, PsychINFO and reference lists was performed to identify peerreviewed articles published between January 2004 and December 2014 in English. Eligible study designs included randomised controlled trials (RCTs) with pre- and post-intervention data. Data extraction and assessment of methodological quality with the Cochrane approach was conducted by two independent reviewers. Seven exercise studies were identified. Exercise significantly improved QoL, but showed no effect on metabolic risk factors (weight, waist circumference, lean or fat mass, blood pressure and lipid profile). Two dietary studies were identified, both of which tested soy supplements. Soy supplementation did not improve any outcomes. No dietary counselling studies were identified. No studies evaluated androgen-deficiency symptoms (libido, erectile function, sleep quality, mood swings, depression, anxiety and bone mineral density). Evidence from RCTs indicates that exercise enhances health- and disease-specific QoL in men with PCa undergoing ADT. Further studies are required to evaluate the effect of exercise and dietary interventions on QoL, androgen deprivation symptoms and metabolic risk factors in this cohort.
Keyword Aerobic exercise
Androgen deprivation therapy
Diet
Prostate cancer
Quality of life
Resistance exercise
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
School of Nursing, Midwifery and Social Work Publications
 
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Created: Wed, 25 Nov 2015, 08:16:51 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work