Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling

Parker, Suzanne L., Roberts, Jason A., Lipman, Jeffrey and Wallis, Steven C. (2015) Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling. Bioanalysis, 7 19: 2585-2595. doi:10.4155/bio.15.173


Author Parker, Suzanne L.
Roberts, Jason A.
Lipman, Jeffrey
Wallis, Steven C.
Title Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling
Journal name Bioanalysis   Check publisher's open access policy
ISSN 1757-6199
1757-6180
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.4155/bio.15.173
Open Access Status Not Open Access
Volume 7
Issue 19
Start page 2585
End page 2595
Total pages 11
Place of publication London, United Kingdom
Publisher Future Science
Collection year 2016
Language eng
Formatted abstract
Background: Fosfomycin is an antibiotic of considerable interest for the treatment of infection by multidrug-resistant bacteria. Translating microsampling techniques into clinical PK studies may provide effective dosing information to improve patient outcomes and minimize the potential development of resistance. Results: Accuracy and precision results were within ±15%; the method was validated across the range of 5–2000 µg/ml of fosfomycin using volumetric absorptive microsampling (VAMS) devices. Conclusion: The VAMS techniques provide acceptable validation data as assessed for lower limit of quantification, linearity, intra- and interday precision and accuracy, selectivity and matrix effects. Results from the recovery and stability studies suggest challenges remain for the analysis of fosfomycin in whole blood using VAMS.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
School of Pharmacy Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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