Meta-analysis identifies seven susceptibility loci involved in the atopic March

Marenholz, Ingo, Esparza-Gordillo, Jorge, Ruschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjorg, Margaritte-Jeannin, Patricia, Saaf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Soderhall, Cilla, Pershagen, Goran, De Jongste, Johan C., Postma, Dirkje S., Braun-Fahrlander, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Y., Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Folster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nothen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hubner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melen, Erik, Dizier, Marie- Helene, Henderson, A. John and Lee, Young Ae (2015) Meta-analysis identifies seven susceptibility loci involved in the atopic March. Nature Communications, 6 8804.1-8804.8. doi:10.1038/ncomms9804

Author Marenholz, Ingo
Esparza-Gordillo, Jorge
Ruschendorf, Franz
Bauerfeind, Anja
Strachan, David P.
Spycher, Ben D.
Baurecht, Hansjorg
Margaritte-Jeannin, Patricia
Saaf, Annika
Kerkhof, Marjan
Ege, Markus
Baltic, Svetlana
Matheson, Melanie C.
Li, Jin
Michel, Sven
Ang, Wei Q.
McArdle, Wendy
Arnold, Andreas
Homuth, Georg
Demenais, Florence
Bouzigon, Emmanuelle
Soderhall, Cilla
Pershagen, Goran
De Jongste, Johan C.
Postma, Dirkje S.
Braun-Fahrlander, Charlotte
Horak, Elisabeth
Ogorodova, Ludmila M.
Puzyrev, Valery P.
Bragina, Elena Y.
Hudson, Thomas J.
Morin, Charles
Duffy, David L.
Marks, Guy B.
Robertson, Colin F.
Montgomery, Grant W.
Musk, Bill
Thompson, Philip J.
Martin, Nicholas G.
James, Alan
Sleiman, Patrick
Toskala, Elina
Rodriguez, Elke
Folster-Holst, Regina
Franke, Andre
Lieb, Wolfgang
Gieger, Christian
Heinzmann, Andrea
Rietschel, Ernst
Keil, Thomas
Cichon, Sven
Nothen, Markus M.
Pennell, Craig E.
Sly, Peter D.
Schmidt, Carsten O.
Matanovic, Anja
Schneider, Valentin
Heinig, Matthias
Hubner, Norbert
Holt, Patrick G.
Lau, Susanne
Kabesch, Michael
Weidinger, Stefan
Hakonarson, Hakon
Ferreira, Manuel A. R.
Laprise, Catherine
Freidin, Maxim B.
Genuneit, Jon
Koppelman, Gerard H.
Melen, Erik
Dizier, Marie- Helene
Henderson, A. John
Lee, Young Ae
Title Meta-analysis identifies seven susceptibility loci involved in the atopic March
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-11-06
Sub-type Article (original research)
DOI 10.1038/ncomms9804
Open Access Status DOI
Volume 6
Start page 8804.1
End page 8804.8
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Child Health Research Centre Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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