Filling the void: allogeneic myeloid cells for transplantation

Schwaber, Jessica L., Brunck, Marion E., Levesque, Jean-Pierre and Nielsen, Lars K. (2015) Filling the void: allogeneic myeloid cells for transplantation. Current Opinion in Hematology, 23 1: 72-77. doi:10.1097/MOH.0000000000000205

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Author Schwaber, Jessica L.
Brunck, Marion E.
Levesque, Jean-Pierre
Nielsen, Lars K.
Title Filling the void: allogeneic myeloid cells for transplantation
Journal name Current Opinion in Hematology   Check publisher's open access policy
ISSN 1531-7048
Publication date 2015-11-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MOH.0000000000000205
Open Access Status Not Open Access
Volume 23
Issue 1
Start page 72
End page 77
Total pages 6
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Formatted abstract
Purpose of review: The success of allogeneic haematopoietic stem and progenitor cell (HSPC) transplantations remains inconsistent. Umbilical cord blood (UCB) is a promising source of HSPCs for transplantation, but low cell yield hampers its widespread use. Multiple strategies are being developed to manipulate UCB to either increase HSPC content or enhance bone marrow homing upon transfusion.

Recent findings: Several ex-vivo manipulation protocols have increased engraftment success in recent phase I/II clinical trials. Additionally, by exploiting knowledge of the transcriptome, mature cells were dedifferentiated into induced haematopoietic stem cells capable of self-renewal and reconstitution of haematopoiesis in vivo.

Summary: UCB is a more readily available source of allogeneic transplant material compared with bone marrow and mobilized peripheral blood. However, the number of HSPCs in a graft is correlated to the rate and success of engraftment and UCB grafts typically contain 10 times less cells compared with bone marrow or mobilized peripheral blood grafts that contain around 1 x 108 CD34+ cells. Recently, research efforts have focused on increasing UCB engrafting cells in addition to the methods to accelerate engraftment or to provide transient protection and support until engraftment succeeds.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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