MHC class II expression is regulated in dendritic cells independently of invariant chain degradation

Villadangos, José A., Cardoso, Marı́a, Steptoe, Raymond J., van Berkel, Dionne, Pooley, Joanne, Carbone, Francis R. and Shortman, Ken (2001) MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. Immunity, 14 6: 739-749. doi:10.1016/S1074-7613(01)00148-0


Author Villadangos, José A.
Cardoso, Marı́a
Steptoe, Raymond J.
van Berkel, Dionne
Pooley, Joanne
Carbone, Francis R.
Shortman, Ken
Title MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2001
Sub-type Article (original research)
DOI 10.1016/S1074-7613(01)00148-0
Volume 14
Issue 6
Start page 739
End page 749
Total pages 11
Place of publication Cambridge
Publisher Cell Press
Language eng
Subject 320000 Medical and Health Sciences
Abstract We have investigated the mechanisms that control MHC class II (MHC II) expression in immature and activated dendritic cells (DC) grown from spleen and bone marrow precursors. Degradation of the MHC II chaperone invariant chain (li), acquisition of peptide cargo by MHC II, and delivery of MHC II-peptide complexes to the cell surface proceeded similarly in both immature and activated DC. However, immature DC reendocytosed and then degraded the MHC II-peptide complexes much faster than the activated DC. MHC II expression in DC is therefore not controlled by the activity of the protease(s) that degrade Ii, but by the rate of endocytosis of peptide-loaded MHC II. Late after activation, DC downregulated MHC II synthesis both in vitro and in vivo.
Keyword Immunology
Cathepsin-s
Antigen Presentation
Surface Expression
Developmental Regulation
Cd8 Expression
Mouse Thymus
Hla-dm
Molecules
Maturation
Transport
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 12:23:23 EST