Warfarin related intracranial haemorrhage: a case-controlled study of anticoagulation monitoring prior to spontaneous subdural or intracerebral haemorrhage

Jeffree, R. L., Gordon, D. H., Sivasubramaniam, R. and Chapman, A. (2009) Warfarin related intracranial haemorrhage: a case-controlled study of anticoagulation monitoring prior to spontaneous subdural or intracerebral haemorrhage. Journal of Clinical Neuroscience, 16 7: 882-885. doi:10.1016/j.jocn.2008.10.004


Author Jeffree, R. L.
Gordon, D. H.
Sivasubramaniam, R.
Chapman, A.
Title Warfarin related intracranial haemorrhage: a case-controlled study of anticoagulation monitoring prior to spontaneous subdural or intracerebral haemorrhage
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2009-07
Sub-type Article (original research)
DOI 10.1016/j.jocn.2008.10.004
Open Access Status Not Open Access
Volume 16
Issue 7
Start page 882
End page 885
Total pages 4
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract We present a retrospective, case-controlled study of the degree of over-warfarinisation and the frequency of International Normalized Ratio (INR) monitoring in patients with spontaneous intracranial haemorrhage (ICH) compared with a control group without ICH. A higher proportion of patients with ICH were taking warfarin than patients in the control group (33/221 [15%] versus 16/201 [8%], p < 0.05). There was no significant difference between the ICH group and the controls in the mean INR of warfarinised patients on presentation, the mean INR when last measured prior to presentation, or in the number of days since the INR was last tested. There was no correlation between the time since the INR was last measured and the INR on presentation. Only 2 (6%) of patients were excessively anticoagulated at the time of ICH. Thus, in this study, warfarin use was associated with an increased risk of ICH despite appropriate community INR monitoring and therapeutic anticoagulation.
Keyword Warfarin
Intracranial haemorrhage
Cerebral haemorrhage
Subdural hematoma
Anticoagulants
International normalized ratio
Complications
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 18 Nov 2015, 14:31:30 EST by Anthony Yeates on behalf of School of Medicine