Current strategies in the surgical management of cerebral metastases: an evidence-based review

Siu, Timothy L., Jeffree, Rosalind L. and Fuller, John W. (2011) Current strategies in the surgical management of cerebral metastases: an evidence-based review. Journal of Clinical Neuroscience, 18 11: 1429-1434. doi:10.1016/j.jocn.2011.04.002


Author Siu, Timothy L.
Jeffree, Rosalind L.
Fuller, John W.
Title Current strategies in the surgical management of cerebral metastases: an evidence-based review
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2011-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jocn.2011.04.002
Open Access Status Not Open Access
Volume 18
Issue 11
Start page 1429
End page 1434
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract Metastatic tumours are the most common form of cerebral neoplasm, occurring in up to 40% of patients with systemic cancer. Although the presence of metastatic disease portends limited survival, aggressive management of cerebral metastases is vital to preventing death from neurological causes and prolonging functional independence. Due to advancement in neurosurgical techniques and the advent of stereotactic radiosurgery as a non-operative alternative, current decision making for selecting the appropriate local treatment often results in clinical equipoise. In addition, the traditional blanket application of whole brain radiation has come under scrutiny as new evidence regarding the deleterious neurocognitive effects of ionizing radiation emerges. The completion of a series of randomized studies comparing the efficacy of surgery, radiosurgery, whole brain radiotherapy and various combined approaches for cerebral metastases in recent years has shed important light on addressing some of these issues. The focus of this review is to summarize the key findings and outline a practical approach for the management of cerebral metastases.
Keyword Cerebral metastases
Stereotactic radiosurgery
Surgery
Treatment outcome
Whole brain radiation therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Wed, 18 Nov 2015, 14:29:52 EST by Anthony Yeates on behalf of School of Medicine