Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees

Biergans, Stephanie D., Galizia, C. Giovanni, Reinhard, Judith and Claudianos, Charles (2015) Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees. Scientific Reports, 5 16223: 1-12. doi:10.1038/srep16223


Author Biergans, Stephanie D.
Galizia, C. Giovanni
Reinhard, Judith
Claudianos, Charles
Title Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees
Formatted title
Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2015-11-04
Year available 2015
Sub-type Article (original research)
DOI 10.1038/srep16223
Open Access Status DOI
Volume 5
Issue 16223
Start page 1
End page 12
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
DNA methylation and demethylation are epigenetic mechanisms involved in memory formation. In honey bees DNA methyltransferase (Dnmt) function is necessary for long-term memory to be stimulus specific (i.e. to reduce generalization). So far, however, it remains elusive which genes are targeted and what the time-course of DNA methylation is during memory formation. Here, we analyse how DNA methylation affects memory retention, gene expression, and differential methylation in stimulus-specific olfactory long-term memory formation. Out of 30 memory-associated genes investigated here, 9 were upregulated following Dnmt inhibition in trained bees. These included Dnmt3 suggesting a negative feedback loop for DNA methylation. Within these genes also the DNA methylation pattern changed during the first 24 hours after training. Interestingly, this was accompanied by sequential activation of the DNA methylation machinery (i.e. Dnmts and Tet). In sum, memory formation involves a temporally complex epigenetic regulation of memory-associated genes that facilitates stimulus specific long-term memory in the honey bee.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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