Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway

Ryu, BoMi, Ahn, Byul-Nim, Kang, Kyong-Hwa, Kim, Young-Sang, Li, Yong-Xin, Kong, Chang-Suk, Kim, Se-Kwon and Kim, Dong Gyu (2015) Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway. Journal of Photochemistry and Photobiology B: Biology, 153 352-357. doi:10.1016/j.jphotobiol.2015.10.018


Author Ryu, BoMi
Ahn, Byul-Nim
Kang, Kyong-Hwa
Kim, Young-Sang
Li, Yong-Xin
Kong, Chang-Suk
Kim, Se-Kwon
Kim, Dong Gyu
Title Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway
Journal name Journal of Photochemistry and Photobiology B: Biology   Check publisher's open access policy
ISSN 1873-2682
1011-1344
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1016/j.jphotobiol.2015.10.018
Open Access Status Not Open Access
Volume 153
Start page 352
End page 357
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Although ultraviolet B (UVB) has a low level of skin penetration, it readily results in epidermal sunburn of keratinocytes that are destined to apoptosis after sun expose, and leads to DNA damage.

Dioxinodehydroeckol (DHE), a phlorotannin from Ecklonia cava has been explored for its preventive activity against UVB-induced apoptosis in human keratinocyte (HaCaT) cells; however, the protective effects of treatment with low doses of DHE on UVB-damaged cells post-UVB exposure and their underlying mechanisms still remain unclear.

The HaCaT cells were exposed to 20 mJ cm−2 of UVB irradiation which is the minimal erythema dose (MED) for individuals to be able to tan, and the expression levels of Bax/Bcl-2 and caspase-3,-8, -9 which are associated genes with apoptosis were investigated when we either treated cells with DHE doses after UVB irradiation or exposed them to UVB only.

Our results suggest insight into proposed mechanistic pathway of protective activity of DHE on the HaCaT cells from UVB-induced apoptosis, indicating the benefit of DHE as a repair agent for skin damage against UVB.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
 
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