Lens shape and refractive index distribution in type 1 diabetes

Adnan, Pope, James M., Sepehrband, Farshid, Suheimat, Marwan, Verkicharla, Pavan K., Kasthurirangan, Sanjeev and Atchison, David A. (2015) Lens shape and refractive index distribution in type 1 diabetes. Investigative Ophthalmology and Visual Science, 56 8: 4759-4766. doi:10.1167/iovs.15-16430

Author Adnan
Pope, James M.
Sepehrband, Farshid
Suheimat, Marwan
Verkicharla, Pavan K.
Kasthurirangan, Sanjeev
Atchison, David A.
Title Lens shape and refractive index distribution in type 1 diabetes
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 1552-5783
Publication date 2015-07
Year available 2015
Sub-type Article (original research)
DOI 10.1167/iovs.15-16430
Open Access Status Not Open Access
Volume 56
Issue 8
Start page 4759
End page 4766
Total pages 8
Place of publication Rockville, United States
Publisher Association for Research in Vision and Ophthalmology
Collection year 2016
Language eng
Formatted abstract
Purpose: To compare lens dimensions and refractive index distributions in type 1 diabetes and age-matched control groups.

Methods: There were 17 participants with type 1 diabetes, consisting of two subgroups (7 young [23 ± 4 years] and 10 older [54 ± 4 years] participants), with 23 controls (13 young, 24 ± 4 years; 10 older, 55 ± 4 years). For each participant, one eye was tested with relaxed accommodation. A 3T clinical magnetic resonance imaging scanner was used to image the eye, employing a multiple spin echo (MSE) sequence to determine lens dimensions and refractive index profiles along the equatorial and axial directions.

Results: The diabetes group had significantly smaller lens equatorial diameters and larger lens axial thicknesses than the control group (diameter mean ± 95% confidence interval [CI]: diabetes group 8.65 ± 0.26 mm, control group 9.42 ± 0.18 mm; axial thickness: diabetes group 4.33 ± 0.30 mm, control group 3.80 ± 0.14 mm). These differences were also significant within each age group. The older group had significantly greater axial thickness than the young group (older group 4.35 ± 0.26 mm, young group 3.70 ± 0.25 mm). Center refractive indices of diabetes and control groups were not significantly different. There were some statistically significant differences between the refractive index fitting parameters of young and older groups, but not between diabetes and control groups of the same age.

Conclusions: Smaller lens diameters occurred in the diabetes groups than in the age-matched control groups. Differences in refractive index distribution between persons with and without diabetes are too small to have important effects on instruments measuring axial thickness.
Keyword Diabetes type 1
Equatorial diameter
Lens dimensions
Lens thickness
Ocular parameters
Refractive index distribution
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
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