A lateralized top-down network for visuospatial attention and neglect

Wang, Jiaojian, Tian, Yanghua, Wang, Mengzhu, Cao, Long, Wu, Huawang, Zhang, Yun, Wang, Kai and Jiang, Tianzi (2015) A lateralized top-down network for visuospatial attention and neglect. Brain Imaging and Behavior, . doi:10.1007/s11682-015-9460-y


Author Wang, Jiaojian
Tian, Yanghua
Wang, Mengzhu
Cao, Long
Wu, Huawang
Zhang, Yun
Wang, Kai
Jiang, Tianzi
Title A lateralized top-down network for visuospatial attention and neglect
Journal name Brain Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7565
1931-7557
Publication date 2015-10-27
Year available 2015
Sub-type Article (original research)
DOI 10.1007/s11682-015-9460-y
Open Access Status Not yet assessed
Total pages 9
Place of publication New York, United States
Publisher Springer
Collection year 2016
Language eng
Formatted abstract
The lateralization of visuospatial attention has been well investigated and demonstrated to be primarily resulting from unbalanced interaction between interhemispheric fronto-parietal networks in previous studies. Many recent studies of top-down attention have reported the neural signatures of its effects within visual cortex and identified its causal basis. However, the relationship between top-down networks and asymmetric visuospatial attention has not been well studied. In the current study, we aimed to explore the relationship between top-down connectivity and asymmetric visuospatial ability by using repetitive transcranial magnetic stimulation (rTMS) and resting-state functional connectivity (RSFC) analyses. We used rTMS and RSFC to model the virtual lesion to assess the behavioral performances in visuospatial attention shifting and to identify the behavior-related top-down functional connectivities, respectively. Furthermore, we also investigated the top-down connectivity in neglect patients to validate the RSFC findings. RSFC analyses in healthy subjects and neglect patients consistently revealed that asymmetric visuospatial ability and visuospatial neglect were closely related to the bias of top-down functional connectivity between posterior superior parietal lobule (SPL) and V1. Our findings indicate that stronger top-down connectivity has stronger dominance on its corresponding visual field. We argue that an asymmetric top-down network may represent a possible neurophysiological substrate for the ongoing functional asymmetry of visuospatial attention, and its interhemispheric unbalanced interaction could contribute to the clinical manifestations of visuospatial neglect.
Keyword Visuospatial attention
Neglect
Superior parietal lobule
Visual cortex
TMS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
 
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Created: Thu, 12 Nov 2015, 11:04:26 EST by Susan Day on behalf of Scholarly Communication and Digitisation Service