Impaired savings despite intact initial learning of motor adaptation in Parkinson's disease

Leow, Li-Ann, Loftus, Andrea M. and Hammond, Geoffrey R. (2012) Impaired savings despite intact initial learning of motor adaptation in Parkinson's disease. Experimental Brain Research, 218 2: 295-304. doi:10.1007/s00221-012-3060-5


Author Leow, Li-Ann
Loftus, Andrea M.
Hammond, Geoffrey R.
Title Impaired savings despite intact initial learning of motor adaptation in Parkinson's disease
Journal name Experimental Brain Research   Check publisher's open access policy
ISSN 0014-4819
1432-1106
Publication date 2012
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s00221-012-3060-5
Open Access Status Not Open Access
Volume 218
Issue 2
Start page 295
End page 304
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract In motor adaptation, the occurrence of savings (faster relearning of a previously learned motor adaptation task) has been explained in terms of operant reinforcement learning (Huang et al. in Neuron 70(4):787-801, 2011), which is thought to associate an adapted motor command with outcome success during repeated execution of the adapted movement. There is some evidence for deficient savings in Parkinson's Disease (PD), which might result from deficient operant reinforcement processes. However, this evidence is compromised by limited adaptation training during initial learning and by multi-target adaptation, which reduces the number of reinforced movement repetitions for each target. Here, we examined savings in PD patients and controls following overlearning with a single target. PD patients showed less savings than controls after successive adaptation and deadaptation blocks within the same test session, as well as less savings across test sessions separated by a 24-h delay. It is argued that impaired blunted dopaminergic signals in PD impairs the modulation of dopaminergic signals to the motor cortex in response to rewarding motor outcomes, thus impairing the association of the adapted motor command with rewarding motor outcomes. Consequently, the previously adapted motor command is not preferentially selected during relearning, and savings is impaired.
Keyword Motor learning
Parkinson's disease
Savings
Visuomotor adaptation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Nov 2015, 15:05:18 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences