Vectored vaccines to protect against PRRSV

Cruz, Jazmina L. G., Zuniga, Sonia, Becares, Martina, Sola, Isabel, Ceriani, Juan E., Juanola, Sandra, Plana, Juan and Enjuanes, Luis (2010) Vectored vaccines to protect against PRRSV. Virus Research, 154 1-2: 150-160. doi:10.1016/j.virusres.2010.06.017


Author Cruz, Jazmina L. G.
Zuniga, Sonia
Becares, Martina
Sola, Isabel
Ceriani, Juan E.
Juanola, Sandra
Plana, Juan
Enjuanes, Luis
Title Vectored vaccines to protect against PRRSV
Journal name Virus Research   Check publisher's open access policy
ISSN 0168-1702
1872-7492
Publication date 2010
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.virusres.2010.06.017
Volume 154
Issue 1-2
Start page 150
End page 160
Total pages 11
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Abstract PRRSV is the causative agent of the most important infectious disease affecting swine herds worldwide, producing great economic losses. Commercially available vaccines are only partially effective in protection against PRRSV. Moreover, modified live vaccines may allow virus shedding, and could revert generating virulent phenotypes. Therefore, new efficient vaccines are required. Vaccines based on recombinant virus genomes (virus vectored vaccines) against PRRSV could represent a safe alternative for the generation of modified live vaccines. In this paper, current vectored vaccines to protect against PRRSV are revised, including those based on pseudorabies virus, poxvirus, adenovirus, and virus replicons. Special attention has been provided to the use of transmissible gastroenteritis virus (TGEV) as vector for the expression of PRRSV antigens. This vector has the capability of expressing high levels of heterologous genes, is a potent interferon-α inducer, and presents antigens in mucosal surfaces, eliciting both secretory and systemic immunity. A TGEV derived vector (rTGEV) was generated, expressing PRRSV wild type or modified GP5 and M proteins, described as the main inducers of neutralizing antibodies and cellular immune response, respectively. Protection experiments showed that vaccinated animals developed a faster and stronger humoral immune response than the non-vaccinated ones. Partial protection in challenged animals was observed, as vaccinated pigs showed decreased lung damage when compared with the non-vaccinated ones. Nevertheless, the level of neutralizing antibodies was low, what may explain the limited protection observed. Several strategies are proposed to improve current rTGEV vectors expressing PRRSV antigens.
Keyword Coronavirus vector
PRRSV
PRRSV vaccine
TGEV
Vectored vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 11 Nov 2015, 11:29:29 EST by Jazmina Gonzalez Cruz on behalf of UQ Diamantina Institute