Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies

Yap, Alpha S., Gomez, Guillermo A. and Parton, Robert G. (2015) Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies. Developmental Cell, 35 1: 12-20. doi:10.1016/j.devcel.2015.09.012


Author Yap, Alpha S.
Gomez, Guillermo A.
Parton, Robert G.
Title Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1878-1551
1534-5807
Publication date 2015-10-12
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.devcel.2015.09.012
Open Access Status Not yet assessed
Volume 35
Issue 1
Start page 12
End page 20
Total pages 9
Place of publication Cambridge, MA, United States
Publisher Cell Press
Collection year 2016
Language eng
Abstract This Perspective considers how classical cadherin cell-cell adhesion receptors are organized at the nanoscale to generate lateral clusters. Recent advances in optical microscopy reveal that clustering constitutes a general feature of cadherin organization, but one that takes diverse forms. Here we consider the molecular mechanisms responsible for cadherin clustering and their functional implications. We frame our discussion in light of what is known about how nanoscale organization is conferred upon the plasma membrane, through protein-protein interactions, regulation of the cortical actin cytoskeleton, and the lipid environment of the membrane.
Keyword Adherens junctions
Cadherin
Cytoskeleton
Membrane organization
Nanoclusters
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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