Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de-differentiation

Samaratunga, Hemamali, Delahunt, Brett, Egevad, Lars, Adamson, Michael, Hussey, David, Malone, Greg, Hoyle, Kirsten, Nathan, Tim, Kerle, David, Ferguson, Peter and Nacey, John N. (2015) Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de-differentiation. Histopathology, 68 4: 533-540. doi:10.1111/his.12785

Author Samaratunga, Hemamali
Delahunt, Brett
Egevad, Lars
Adamson, Michael
Hussey, David
Malone, Greg
Hoyle, Kirsten
Nathan, Tim
Kerle, David
Ferguson, Peter
Nacey, John N.
Title Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de-differentiation
Journal name Histopathology   Check publisher's open access policy
ISSN 1365-2559
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1111/his.12785
Open Access Status Not Open Access
Volume 68
Issue 4
Start page 533
End page 540
Total pages 8
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Vesical pleomorphic giant cell carcinoma (PGCC) is a variant of urothelial carcinoma (UC) characterized by highly pleomorphic tumour with giant cells. Fewer than 10 cases have been reported, and our aim was to determine the clinical and pathological features of a series of tumours from a specialized uropathology laboratory.

Methods and results
Thirteen cases of PGCC of the bladder were identified. There were nine males and four females, ranging in age from 53 to 92 years (mean 72 years). Associated conventional high-grade UC was seen in eight cases, while three cases also had micropapillary UC and one plasmacytoid UC. UC in situ (CIS) was present in five cases and occasional bizarre cells were seen in both UC and CIS. The proportion of PGCC present varied from 40% to 100% of tumour. Immunostaining performed on 10 cases showed uniform positivity for CK 8/18 and AE1/AE3, while most tumours were positive for CK7, CK20, uroplakin III and GATA binding protein 3 (GATA3). β-human chorionic gonadotrophin (β-hCG) was negative. Of 10 patients with follow-up, five died within 1 year and four are alive with tumour.

The association of PGCC with UC and an overlap in immunoexpression suggests that PGCC represents an extreme form of UC de-differentiation.
Keyword Bladder
Pleomorphic giant cell carcinoma
Urothelial carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
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