Antibiotic dose optimization in critically ill patients / Optimización de la dosis de antibióticos en pacientes críticamente enfermos

Cotta, M. O., Roberts, J. A. and Lipman, J. (2015) Antibiotic dose optimization in critically ill patients / Optimización de la dosis de antibióticos en pacientes críticamente enfermos. Medicina Intensiva (English Edition), 39 9: 563-572. doi:10.1016/j.medine.2015.07.001

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Author Cotta, M. O.
Roberts, J. A.
Lipman, J.
Title Antibiotic dose optimization in critically ill patients / Optimización de la dosis de antibióticos en pacientes críticamente enfermos
Journal name Medicina Intensiva (English Edition)   Check publisher's open access policy
ISSN 2173-5727
0210-5691
1697-154X
1578-6749
Publication date 2015-12
Sub-type Article (original research)
DOI 10.1016/j.medine.2015.07.001
Open Access Status Not Open Access
Volume 39
Issue 9
Start page 563
End page 572
Total pages 10
Place of publication Barcelona, Spain
Publisher Elsevier Espana
Collection year 2016
Language eng
Abstract The judicious use of existing antibiotics is essential for preserving their activity against infections. In the era of multi-drug resistance, this is of particular importance in clinical areas characterized by high antibiotic use, such as the ICU. Antibiotic dose optimization in critically ill patients requires sound knowledge not only of the altered physiology in serious infections – including severe sepsis, septic shock and ventilator-associated pneumonia – but also of the pathogen–drug exposure relationship (i.e. pharmacokinetic/pharmacodynamic index). An important consideration is the fact that extreme shifts in organ function, such as those seen in hyperdynamic patients or those with multiple organ dysfunction syndrome, can have an impact upon drug exposure, and constant vigilance is required when reviewing antibiotic dosing regimens in the critically ill. The use of continuous renal replacement therapy and extracorporeal membrane oxygenation remain important interventions in these patients; however, both of these treatments can have a profound effect on antibiotic exposure. We suggest placing emphasis on the use of therapeutic drug monitoring and dose individualization when optimizing therapy in these settings.
Keyword Antibiotics
Critically ill
Dose optimization
Septic shock
Severe sepsis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
School of Pharmacy Publications
 
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