Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach

Soo, Ernest, Thakur, Sachin, Qu, Zhi, Jambhrunkar, Siddharth, Parekh, Harebdra S. and Popat, Amirali (2016) Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach. Journal of Colloid and Interface Science, 462 368-374. doi:10.1016/j.jcis.2015.10.022


Author Soo, Ernest
Thakur, Sachin
Qu, Zhi
Jambhrunkar, Siddharth
Parekh, Harebdra S.
Popat, Amirali
Title Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach
Journal name Journal of Colloid and Interface Science   Check publisher's open access policy
ISSN 1095-7103
0021-9797
Publication date 2016-01-15
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jcis.2015.10.022
Open Access Status Not Open Access
Volume 462
Start page 368
End page 374
Total pages 7
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Collection year 2016
Language eng
Abstract Despite the known anticancer potential of resveratrol, its clinical applications are often hindered by physicochemical limitations such as poor solubility and stability. The encapsulation of resveratrol in formulations such as polymeric nanoparticles and liposomes has shown limited success. This study aimed to develop and optimize a novel drug carrier by co-encapsulating pristine resveratrol alongside cyclodextrin–resveratrol inclusion complexes in the lipophilic and hydrophilic compartments of liposomes, respectively by using a novel dual carrier approach. The particle size, polydispersity index and zeta potential of the final formulation were 131 ± 1.30 nm, 0.089 ± 0.005 and −2.64 ± 0.51 mV, respectively. Compared to free resveratrol and conventional liposomal formulations with drug release profile of 40–60%, our novel nanoformulations showed complete (100%) drug release in 24 h. The formulation was stable for 14 days at 4 °C. We also studied the in vitro cytotoxicity of resveratrol encapsulated liposomes in HT-29 colon cancer cell lines. The cytotoxicity profile of our liposomes was observed to be dose dependent and enhanced in comparison to free resveratrol (in DMSO). Our study demonstrates that co-encapsulation of pristine resveratrol along with its cyclodextrin complex in liposomal formulations is a plausible option for the enhanced delivery of the hydrophobic chemotherapeutic agent.
Keyword Resveratrol
Cyclodextrin
Liposome
Anticancer
Nanoparticles
Colorectal cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Pharmacy Publications
 
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