Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins

Guidone, Daniel, Getachew, Robel, Osman, Narin, Ward, Michael, Chan, Vincent and Little, Peter J. (2015) Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins. Clinical and Experimental Pharmacology, 5 3: 1000174.1-1000174.4. doi:10.4172/2161-1459.1000174


Author Guidone, Daniel
Getachew, Robel
Osman, Narin
Ward, Michael
Chan, Vincent
Little, Peter J.
Title Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins
Formatted title
Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins
Journal name Clinical and Experimental Pharmacology   Check publisher's open access policy
ISSN 2161-1459
Publication date 2015-04-30
Sub-type Article (original research)
DOI 10.4172/2161-1459.1000174
Open Access Status DOI
Volume 5
Issue 3
Start page 1000174.1
End page 1000174.4
Total pages 4
Place of publication Los Angeles, CA, United States
Publisher Omics Publishing
Collection year 2016
Language eng
Formatted abstract
Sodium fusidate (fusidic acid) is an antimicrobial agent used to treat methicillin-resistant Staphylococcus aureus infections. Several case reports have described drug interactions between sodium fusidate and CYP3A4 metabolised statins, leading to statin myotoxicity, including fatal myotoxicity. The mechanism of this interaction is unknown. We investigated the effects of sodium fusidate on recombinant CYP3A4 in vitro and found it to be a time dependent inhibitor of this enzyme at concentrations likely to be achieved with clinical dosing regimens. This finding may help to explain the mechanism of the apparent statin-fusidate interaction.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
 
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Created: Fri, 06 Nov 2015, 09:02:54 EST by Ms Felicity Lindberg on behalf of School of Pharmacy