Evaluation of perioperative predictors of acute kidney injury post orthotopic liver transplantation

Wyssusek, K. H., Keys, A. L. B., Yung, J., Moloney, E. T., Sivalingam, P. and Paul, S. K. (2015) Evaluation of perioperative predictors of acute kidney injury post orthotopic liver transplantation. Anaesthesia and Intensive Care, 43 6: 757-763.

Author Wyssusek, K. H.
Keys, A. L. B.
Yung, J.
Moloney, E. T.
Sivalingam, P.
Paul, S. K.
Title Evaluation of perioperative predictors of acute kidney injury post orthotopic liver transplantation
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 2015-11-05
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 43
Issue 6
Start page 757
End page 763
Total pages 7
Place of publication North Sydney, NSW, Australia
Publisher Australian Society of Anaesthetists
Collection year 2016
Language eng
Abstract Acute kidney injury (AKI) is a common complication following orthotopic liver transplantation. It is associated with increased morbidity and mortality, as well as increased healthcare costs. The aetiology of AKI post liver transplantation is multifactorial and understanding these factors is pivotal in developing risk stratification and prevention strategies. This study aims to investigate the preoperative and intraoperative factors that may be associated with AKI in patients undergoing liver transplantation at the Princess Alexandra Hospital, Brisbane, Queensland. In our study, retrospective data of 97 consecutive orthotopic liver transplantations performed between January 2009 and August 2012 were recorded. Univariate and multivariate analyses were performed to investigate the preoperative and intraoperative risk factors for the development of AKI in this cohort. In the cohort of 97 patients who underwent orthotopic liver transplantation, 24 patients (25%) developed postoperative AKI. Univariate analysis demonstrated that high preoperative body mass index and intraoperative noradrenaline use were both associated with AKI. Multivariate analysis demonstrated that high body mass index, high Model for End-stage Liver Disease score and intraoperative noradrenaline use were associated with AKI. Overall mortaility was 4.1% during the study period and was not significantly different between the two groups. The high incidence of AKI following liver transplantation in this study cohort highlights the importance of this issue. This study has identified several potential pre- and intraoperative risk factors, providing a focus for patient surveillance and future research.
Keyword Acute kidney injury
Liver Transplantation
Body mass index
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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Created: Wed, 04 Nov 2015, 22:21:00 EST by Dr Kerstin Wyssusek on behalf of Anaesthesiology and Critical Care - PAH