From mice to humans: Developments in cancer immunoediting

Teng, Michele W. L., Galon, Jerome, Fridman, Wolf-Herman and Smyth, Mark J. (2015) From mice to humans: Developments in cancer immunoediting. Journal of Clinical Investigation, 125 9: 3338-3346. doi:10.1172/JCI80004

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Author Teng, Michele W. L.
Galon, Jerome
Fridman, Wolf-Herman
Smyth, Mark J.
Title From mice to humans: Developments in cancer immunoediting
Journal name Journal of Clinical Investigation   Check publisher's open access policy
ISSN 1558-8238
0021-9738
Publication date 2015-09-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1172/JCI80004
Open Access Status File (Publisher version)
Volume 125
Issue 9
Start page 3338
End page 3346
Total pages 9
Place of publication Ann Arbor, MI, United States
Publisher American Society for Clinical Investigation
Collection year 2016
Language eng
Formatted abstract
Cancer immunoediting explains the dual role by which the immune system can both suppress and/or promote tumor growth. Although cancer immunoediting was first demonstrated using mouse models of cancer, strong evidence that it occurs in human cancers is now accumulating. In particular, the importance of CD8+ T cells in cancer immunoediting has been shown, and more broadly in those tumors with an adaptive immune resistance phenotype. This Review describes the characteristics of the adaptive immune resistance tumor microenvironment and discusses data obtained in mouse and human settings. The role of other immune cells and factors influencing the effector function of tumor-specific CD8+ T cells is covered. We also discuss the temporal occurrence of cancer immunoediting in metastases and whether it differs from immunoediting in the primary tumor of origin.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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