Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility?

Kussmann, Martin, Krause, Lutz and Siffert, Winfried (2010) Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility?. Nutrition Reviews, 68 SUPPL. 1: S38-S47. doi:10.1111/j.1753-4887.2010.00326.x


Author Kussmann, Martin
Krause, Lutz
Siffert, Winfried
Title Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility?
Journal name Nutrition Reviews   Check publisher's open access policy
ISSN 0029-6643
1753-4887
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1111/j.1753-4887.2010.00326.x
Open Access Status Not Open Access
Volume 68
Issue SUPPL. 1
Start page S38
End page S47
Total pages 1
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract The revelation of the human genome has enabled scientists to assess the disposition and response of an organism to an environmental stimulus; transcriptomics, proteomics, and metabonomics can each generate such holistic views. Nutrigenomic techniques help researchers elucidate individual responses to nutritional interventions holistically and help with the design of personalized diets adapted to individual needs. Human genetics has revealed insights into health and disease susceptibility and can help differentiate responders from nonresponders in dietary interventions, but the predictive power of single-nucleotide polymorphisms in disease susceptibility genes has so far been limited in terms of helping to foresee a health trajectory. Epigenetics encompasses alterations of genetic material that do not affect the DNA nucleotide sequence; these include DNA methylation patterns, chromatin structure, histone codes, and non-coding small RNAs. DNA methylation is modified particularly around the time of birth; therefore, early-life nutrition may affect health outcomes later in life.
Keyword Biomarker
Brain
Cognition
Epigenetics
Nutrigenetics
Nutrigenomics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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