Impact of dietary dairy polar lipids on lipid metabolism of mice fed a high-fat diet

Reis, Mariza G., Roy, Nicole C., Bermingham, Emma N., Ryan, Leigh, Bibiloni, Rodrigo, Young, Wayne, Krause, Lutz, Berger, Bernard, North, Mike, Stelwagen, Kerst and Reis, Marlon M. (2013) Impact of dietary dairy polar lipids on lipid metabolism of mice fed a high-fat diet. Journal of Agricultural and Food Chemistry, 61 11: 2729-2738. doi:10.1021/jf303795b


Author Reis, Mariza G.
Roy, Nicole C.
Bermingham, Emma N.
Ryan, Leigh
Bibiloni, Rodrigo
Young, Wayne
Krause, Lutz
Berger, Bernard
North, Mike
Stelwagen, Kerst
Reis, Marlon M.
Title Impact of dietary dairy polar lipids on lipid metabolism of mice fed a high-fat diet
Journal name Journal of Agricultural and Food Chemistry   Check publisher's open access policy
ISSN 0021-8561
1520-5118
Publication date 2013-03-20
Sub-type Article (original research)
DOI 10.1021/jf303795b
Open Access Status Not Open Access
Volume 61
Issue 11
Start page 2729
End page 2738
Total pages 10
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Abstract The effect of milk polar lipids on lipid metabolism of liver, adipose tissue, and brain and on composition of intestinal microbiota was investigated. C57BL/6J mice were fed a high-fat diet (HFD) for 5 weeks, followed by 5 weeks with HFD without (control) or supplemented with total polar lipids (TPL), phospholipids (PL), or sphingolipids (SPL). Animals fed SPL showed a tendency for lower triglyceride synthesis (P = 0.058) in the liver, but not in adipose tissue. PL and TPL reduced de novo hepatic fatty acid biosynthesis. The ratio of palmitoleic to palmitic acid in the liver was lower for animals fed SPL or TPL compared to control. There was little effect of the supplementation on the cecal microbiota composition. In the brain, DHA (C22:6) content correlated negatively with tetracosanoic acid (C24:0) after TPL supplementation (-0.71, P = 0.02) but not in control (0.26, P = 0.44). Arachidonic acid (C20:4) was negatively correlated with C24:0 in both groups (TPL, -0.77, P = 0.008; control, -0.81, P = 0.003).
Keyword Brain lipid metabolism
Cecal microbiota
Dairy polar lipids
Diet-induced obesity
Mass isotopomer distribution analysis
Metabolic syndrome
Phospholipids
Sphingolipids
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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