Recent advances in the development of subunit-based RSV vaccines.

Jaberolansar, Noushin, Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2015) Recent advances in the development of subunit-based RSV vaccines.. Expert Review of Vaccines, 15 1: 53-68. doi:10.1586/14760584.2016.1105134

Author Jaberolansar, Noushin
Toth, Istvan
Young, Paul R.
Skwarczynski, Mariusz
Title Recent advances in the development of subunit-based RSV vaccines.
Journal name Expert Review of Vaccines   Check publisher's open access policy
ISSN 1476-0584
Publication date 2015-10-27
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/14760584.2016.1105134
Open Access Status Not yet assessed
Volume 15
Issue 1
Start page 53
End page 68
Total pages 16
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2016
Language eng
Abstract Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections causing pneumonia and bronchiolitis in infants. RSV also causes serious illness in elderly populations, immunocompromised patients and individuals with pulmonary or cardiac problems. The significant morbidity and mortality associated with RSV infection have prompted interest in RSV vaccine development. In the 1960s, a formalin-inactivated vaccine trial failed to protect children, and indeed enhanced pathology when naturally infected later with RSV. Hence, an alternative approach to traditional killed virus vaccines, which can induce protective immunity without serious adverse events, is desired. Several strategies have been explored in attempts to produce effective vaccine candidates including gene-based and subunit vaccines. Subunit-based vaccine approaches have shown promising efficacy in animal studies and several have reached clinical trials. The current stage of development of subunit-based vaccines against RSV is reviewed in this article.
Keyword Nanoparticles
respiratory syncytial virus
subunit vaccine
virus-like particles
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 30 Oct 2015, 12:15:44 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences