Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery

Ahmad Nor, Yusilawati, Niu, Yuting, Karmakar, Surajit, Zhou, Liang, Xu, Chun, Zhang, Jun, Zhang, Hongwei, Yu, Meihua, Mahony, Donna, Mitter, Neena, Cooper, Matthew and Yu, Cheng Zhong (2015) Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery. ACS Central Science, 1 328-334. doi:10.1021/acscentsci.5b00199

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Author Ahmad Nor, Yusilawati
Niu, Yuting
Karmakar, Surajit
Zhou, Liang
Xu, Chun
Zhang, Jun
Zhang, Hongwei
Yu, Meihua
Mahony, Donna
Mitter, Neena
Cooper, Matthew
Yu, Cheng Zhong
Title Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery
Journal name ACS Central Science   Check publisher's open access policy
ISSN 2374-7951
Publication date 2015-09-09
Year available 2015
Sub-type Article (original research)
DOI 10.1021/acscentsci.5b00199
Open Access Status File (Publisher version)
Volume 1
Start page 328
End page 334
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2016
Language eng
Abstract Inspired by the lotus effect in nature, surface roughness engineering has led to novel materials and applications in many fields. Despite the rapid progress in superhydrophobic and superoleophobic materials, this concept of Mother Nature’s choice is yet to be applied in the design of advanced nanocarriers for drug delivery. Pioneering work has emerged in the development of nanoparticles with rough surfaces for gene delivery; however, the preparation of nanoparticles with hydrophilic compositions but with enhanced hydrophobic property at the nanoscale level employing surface topology engineering remains a challenge. Herein we report for the first time the unique properties of mesoporous hollow silica (MHS) nanospheres with controlled surface roughness. Compared to MHS with a smooth surface, rough mesoporous hollow silica (RMHS) nanoparticles with the same hydrophilic composition show unusual hydrophobicity, leading to higher adsorption of a range of hydrophobic molecules and controlled release of hydrophilic molecules. RMHS loaded with vancomycin exhibits an enhanced antibacterial effect. Our strategy provides a new pathway in the design of novel nanocarriers for diverse bioapplications.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Tue, 27 Oct 2015, 11:35:09 EST by Susan Allen on behalf of Office of the Vice-Chancellor