Cohort Profile: The Barwon Infant Study

Vuillermin, Peter, Saffery, Richard, Allen, Katrina J., Carlin, John B., Tang, Mimi LK, Ranganathan, Sarath, Burgner, David, Dwyer, Terry, Collier, Fiona, Jachno, Kim, Sly, Peter, Symeonides, Christos, McCloskey, Kathleen, Molloy, John, Forrester, Michael and Ponsonby, Anne-Louise (2015) Cohort Profile: The Barwon Infant Study. International Journal of Epidemiology, 44 4: 1148-1160. doi:10.1093/ije/dyv026

Author Vuillermin, Peter
Saffery, Richard
Allen, Katrina J.
Carlin, John B.
Tang, Mimi LK
Ranganathan, Sarath
Burgner, David
Dwyer, Terry
Collier, Fiona
Jachno, Kim
Sly, Peter
Symeonides, Christos
McCloskey, Kathleen
Molloy, John
Forrester, Michael
Ponsonby, Anne-Louise
Title Cohort Profile: The Barwon Infant Study
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 1464-3685
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/ije/dyv026
Open Access Status Not yet assessed
Volume 44
Issue 4
Start page 1148
End page 1160
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [] or via [].
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Child Health Research Centre Publications
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