Cyclotides in the Rubiaceae

Koehbach, Johannes and Gruber, Christian W. (2015) Cyclotides in the Rubiaceae. Advances in Botanical Research, 76 51-78. doi:10.1016/bs.abr.2015.09.002

Author Koehbach, Johannes
Gruber, Christian W.
Title Cyclotides in the Rubiaceae
Journal name Advances in Botanical Research   Check publisher's open access policy
ISSN 0065-2296
ISBN 978-0-12-800030-4
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1016/bs.abr.2015.09.002
Open Access Status Not Open Access
Volume 76
Start page 51
End page 78
Total pages 28
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Collection year 2016
Language eng
Formatted abstract
Cyclotides are small disulfide-rich plant peptides. Their unique structural features, intrinsic bioactivities, and enormous sequence diversity make them interesting molecules for pharmaceutical applications. So far the amino acid sequences of nearly 400 individual cyclotides have been reported and they have been discovered in plant species of the Violaceae, Cucurbitaceae, Fabaceae, Solanaceae, Poaceae, and Rubiaceae families. Rubiaceae is the fourth largest angiosperm family and comprises about 650 genera and 13,000 species. The family includes coffee, which is a major export commodity and it was the top agricultural export for 12 countries in 2004, as well as the world's seventh largest legal agricultural export by value in 2005. Additionally, the family comprises timber species such as bilinga, many ornamental plants, and important plants of medicinal purpose such as quinine and ipecac. In part due to the wide geographical distribution, plants of the coffee family are estimated to constitute about 8% of the world's flora. In this book chapter, we will (1) summarize our efforts to identify and characterize novel cyclotide-expressing plants within the Rubiaceae family, (2) analyze the sequence diversity of cyclotides from Rubiaceae, (3) discuss their evolution in flowering plants based on the distribution of cyclotide-bearing Rubiaceae species, and (4) provide a brief overview of bioactive properties of cyclotides that have been isolated from Rubiaceae plant species. Based on studies of cyclotides in Rubiaceae their number has been predicted to be greater than 50,000 and we believe cyclotides are one of the largest protein families within the plant kingdom.
Keyword Apocynaceae
Circular peptides
Cystine Knot
Mass spectrometry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
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