Nonmelanoma cutaneous head and neck cancer and merkel cell carcinoma: Current concepts, advances, and controversies

Porceddu, Sandro V., Veness, Michael J. and Guminski, Alexander (2015) Nonmelanoma cutaneous head and neck cancer and merkel cell carcinoma: Current concepts, advances, and controversies. Journal of Clinical Oncology, 33 29: 3338-3345. doi:10.1200/JCO.2014.60.7333


Author Porceddu, Sandro V.
Veness, Michael J.
Guminski, Alexander
Title Nonmelanoma cutaneous head and neck cancer and merkel cell carcinoma: Current concepts, advances, and controversies
Journal name Journal of Clinical Oncology   Check publisher's open access policy
ISSN 0732-183X
1527-7755
Publication date 2015-10-10
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1200/JCO.2014.60.7333
Open Access Status Not Open Access
Volume 33
Issue 29
Start page 3338
End page 3345
Total pages 8
Place of publication Alexandria, VA United States
Publisher American Society of Clinical Oncology
Collection year 2016
Language eng
Formatted abstract
Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the most frequently observed malignancy in whites. Approximately 75% to 80% are basal cell carcinomas and 20% to 25% are squamous cell carcinomas. Incidence is increasing, partly reflecting an ageing population, and NMSC is more commonly seen in men. The predominant causative agent is ultraviolet solar radiation exposure, with the majority of cases occurring on the head and neck. Surgical excision is typically the treatment of choice, providing histopathologic information, high cure rates, and acceptable cosmetic and functional outcomes. Radiation therapy is reserved for cases where surgery is not the preferred choice or for high-risk cases where adjuvant therapy is recommended. Although overall mortality rates are low, patients with complex cases such as those with immunosuppression should be considered for management within multidisciplinary tumor boards. In contrast, Merkel cell carcinoma is a rare and aggressive malignancy, frequently arising on the head and neck in older whites, with a poorer prognosis. This article focuses on the current evidence guiding practice, recent advances, and areas of controversy in NMSC and Merkel cell carcinoma of the head and neck.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 27 Oct 2015, 00:23:10 EST by System User on behalf of Medicine - Princess Alexandra Hospital