High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Tucker, Patrick S., Briskey, David R., Scanlan, Aaron T., Coombes, Jeff S. and Dalbo, Vincent J. (2015) High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease. Free Radical Biology and Medicine, 89 466-472. doi:10.1016/j.freeradbiomed.2015.07.162

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Author Tucker, Patrick S.
Briskey, David R.
Scanlan, Aaron T.
Coombes, Jeff S.
Dalbo, Vincent J.
Title High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease
Journal name Free Radical Biology and Medicine   Check publisher's open access policy
ISSN 0891-5849
1873-4596
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.freeradbiomed.2015.07.162
Open Access Status File (Author Post-print)
Volume 89
Start page 466
End page 472
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO2max), versus low intensity exercise (45–50% VO2max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (p<0.001). Compared to low intensity exercise, high intensity interval training resulted in increased mRNA expression of Cat (p<0.001) and Tnfrsf1b (p=0.047). In this study, high intensity interval training was superior to sedentary behaviour and low intensity exercise as high intensity interval training beneficially influenced expression of genes related to endogenous antioxidant enzyme activity and inflammation.
Keyword Antioxidant status
Exercise
High intensity interval training
Nephrology
Reactive oxygen species
Renal disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
 
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