Effect of food and dosage on cimicoxib pharmacokinetics in dogs

Lebkowska-Wieruszewska, Beata, Kowalski, Cezary Jacek, Kim, Tae Won, Owen, Helen, Yun, Hyoin and Giorgi, Mario (2015) Effect of food and dosage on cimicoxib pharmacokinetics in dogs. Medycyna Weterynaryjna - Veterinary Medicine-Science and Practice, 71 10: 626-631.

Author Lebkowska-Wieruszewska, Beata
Kowalski, Cezary Jacek
Kim, Tae Won
Owen, Helen
Yun, Hyoin
Giorgi, Mario
Title Effect of food and dosage on cimicoxib pharmacokinetics in dogs
Translated title Effect of food and dosage on cimicoxib pharmacokinetics in dogs
Language of Title pol
Journal name Medycyna Weterynaryjna - Veterinary Medicine-Science and Practice   Check publisher's open access policy
Translated journal name Veterinary Medicine-Science and Practice
Language of Journal Name pol
ISSN 0025-8628
Publication date 2015-10
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 71
Issue 10
Start page 626
End page 631
Total pages 6
Place of publication Lublin, Poland
Publisher Polskie Towarzystwo Nauk Weterynaryjnych / Polish Society of Veterinary Sciences
Collection year 2016
Language pol
Abstract Cimicoxib (CX) is a new non-steroidal anti-inflammatory drug from the "coxib" family, designed for dogs. In the available literature there is little information on the pharmacokinetics of CX. The aim of this study was to evaluate the effect of food intake on the pharmacokinetic characteristics of cimicoxib. Additionally, the pharmacoldnetic profile after the administration of precise doses of CX (2 mg/kg b.w.) and an approximate dose (i.e. 80 mg tablet for animals of about 40 kg) were estimated. CX concentrations were determined by a HPLC validated method. The results of pharmacokinetic analysis were similar in both studies, regardless of the dose and the degree of filling of the gastrointestinal tract (fasted, fed). In addition, we estimated the duration of the minimum effective concentration (MEC), which turned out to be similar for all the concentrations tested. The results show that neither small variations in dosage nor the presence of food in the gastrointestinal tract change the therapeutic efficacy of the analgesic in terms of its blood concentration.
Keyword cimicoxib
dogs
pharmacokinetic
food
Canine Osteoarthritis
Cox-2 Inhibitor
Safety
Efficacy
Cyclooxygenase-2
Absorption
Firocoxib
Pain
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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