Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design

Lim, Paul C. C. and Layton, Christopher J. (2016) Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design. Clinical and Experimental Ophthalmology, 44 5: 410-421. doi:10.1111/ceo.12671


Author Lim, Paul C. C.
Layton, Christopher J.
Title Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design
Journal name Clinical and Experimental Ophthalmology   Check publisher's open access policy
ISSN 1442-6404
1442-9071
Publication date 2016-01-26
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/ceo.12671
Open Access Status Not Open Access
Volume 44
Issue 5
Start page 410
End page 421
Total pages 12
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Collection year 2017
Language eng
Abstract Clinical prognostic markers in atrophic age-related macular degeneration include the extent of existing atrophy, fundus autofluorescence (FAF) patterns and optical coherence tomography changes in the outer retina/retinal pigment epithelium interface. The prognostic implications of these findings may be used to determine not just the rate of disease progression but also influence the likelihood, magnitude and clinical relevance of therapy responses. FAF phenotypes have been extensively investigated; however, the pathophysiological mechanisms behind their appearance have not been fully elucidated. Optical coherence tomography imaging is additive to FAF imaging in atrophic age-related macular degeneration, allowing the visualization of detail not available through FAF imaging whilst also displaying subtle changes correlating with the FAF phenotypes themselves, thereby giving clues to their histological determinates. The developing understanding of these imaging modalities and consequent development of prognostically useful classification systems have widespread implication in clinical care and clinical trial design.
Keyword Atrophic age-related macular degeneration
Clinical trials
Fundus autofluorescence
Optical coherence tomography
Phenotypes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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Created: Thu, 22 Oct 2015, 08:46:36 EST by Christopher James Layton on behalf of Surgery - Greenslopes Private Hospital