Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis

Kenna, Tony J., Robinson, Philip C. and Haroon, Nigil (2015) Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis. Rheumatology (United Kingdom), 54 9: 1549-1556. doi:10.1093/rheumatology/kev218


Author Kenna, Tony J.
Robinson, Philip C.
Haroon, Nigil
Title Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis
Journal name Rheumatology (United Kingdom)   Check publisher's open access policy
ISSN 1462-0332
1462-0324
Publication date 2015-06-11
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/rheumatology/kev218
Open Access Status Not Open Access
Volume 54
Issue 9
Start page 1549
End page 1556
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Abstract There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this manner and are of particular interest. There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules. Recent studies on the structure, immunological effects and the peptide-trimming properties of ERAP 1 and 2 have helped to provide insight into their pathogenic potential in AS. In this review, we explore the role of ERAP 1 and 2 in the pathogenesis of AS.
Keyword Aminopeptidase
Endoplasmic reticulum resident aminopeptidase 1
Endoplasmic reticulum resident aminopeptidase 2
Endoplasmic reticulum
Unfolded protein response
T cell response
NK cell
Peptide
Misfolding
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
 
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