Life-long implications of developmental exposure to environmental stressors: New perspectives

Grandjean, Philippe, Barouki, Robert, Bellinger, David C., Casteleyn, Ludwine, Chadwick, Lisa H., Cordier, Sylvaine, Etzel, Ruth A., Gray, Kimberly A., Ha, Eun-Hee, Junien, Claudine, Karagas, Margaret, Kawamoto, Toshihiro, Lawrence, B.Paige, Perera, Frederica P., Prins, Gail S., Puga, Alvaro, Rosenfeld, Cheryl S., Sherr, David H., Sly, Peter D., Suk, William, Sun, Qi, Toppari, Jorma, Van Den Hazel, Peter, Walker, Cherlyl L. and Heindel, Jerrold J. (2015) Life-long implications of developmental exposure to environmental stressors: New perspectives. Endocrinology, 156 10: 3408-3415. doi:10.1210/EN.2015-1350


Author Grandjean, Philippe
Barouki, Robert
Bellinger, David C.
Casteleyn, Ludwine
Chadwick, Lisa H.
Cordier, Sylvaine
Etzel, Ruth A.
Gray, Kimberly A.
Ha, Eun-Hee
Junien, Claudine
Karagas, Margaret
Kawamoto, Toshihiro
Lawrence, B.Paige
Perera, Frederica P.
Prins, Gail S.
Puga, Alvaro
Rosenfeld, Cheryl S.
Sherr, David H.
Sly, Peter D.
Suk, William
Sun, Qi
Toppari, Jorma
Van Den Hazel, Peter
Walker, Cherlyl L.
Heindel, Jerrold J.
Title Life-long implications of developmental exposure to environmental stressors: New perspectives
Journal name Endocrinology   Check publisher's open access policy
ISSN 1945-7170
0013-7227
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1210/EN.2015-1350
Open Access Status Not Open Access
Volume 156
Issue 10
Start page 3408
End page 3415
Total pages 8
Place of publication Chevy Chase, Maryland, United States
Publisher The Endocrine Society
Collection year 2016
Language eng
Abstract The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors that can impact on DOHaD encompass a variety of environmental and occupational hazards as well as deficiency and oversupply of nutrients and energy. They can disrupt early developmental processes and lead to increased susceptibility to disease/dysfunctions later in life. Presentations at the fourth Conference on Prenatal Programming and Toxicity in Boston, in October 2014, provided important insights and led to new recommendations for research and public health action. The conference highlighted vulnerable exposure windows that can occur as early as the preconception period and epigenetics as a major mechanism than can lead to disadvantageous “reprogramming” of the genome, thereby potentially resulting in transgenerational effects. Stem cells can also be targets of environmental stressors, thus paving another way for effects that may last a lifetime. Current testing paradigms do not allow proper characterization of risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated. DOHaD-based research has a crucial role in establishing factors leading to detrimental outcomes and developing early preventative/remediation strategies to combat these risks.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Child Health Research Centre Publications
 
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