Developmental origins of health and disease: Integrating environmental influences

Heindel, Jerrold J., Balbus, John, Birnbaum, Linda, Brune-Drisse, Marie Noel, Grandjean, Philippe, Gray, Kimberly, Landrigan, Philip J., Sly, Peter D., Suk, William, Slechta, Deborah Cory, Thompson, Claudia and Hanson, Mark (2015) Developmental origins of health and disease: Integrating environmental influences. Endocrinology, 156 10: 3416-3421. doi:10.1210/EN.2015-1394


Author Heindel, Jerrold J.
Balbus, John
Birnbaum, Linda
Brune-Drisse, Marie Noel
Grandjean, Philippe
Gray, Kimberly
Landrigan, Philip J.
Sly, Peter D.
Suk, William
Slechta, Deborah Cory
Thompson, Claudia
Hanson, Mark
Title Developmental origins of health and disease: Integrating environmental influences
Journal name Endocrinology   Check publisher's open access policy
ISSN 1945-7170
0013-7227
Publication date 2015-10-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1210/EN.2015-1394
Open Access Status Not Open Access
Volume 156
Issue 10
Start page 3416
End page 3421
Total pages 6
Place of publication Chevy Chase, Maryland, United States
Publisher The Endocrine Society
Collection year 2016
Language eng
Abstract There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned with understanding the pathophysiological basis for how environmental influences acting during early development influence the risk of later noncommunicable diseases. Similarly, there is no global research or public health program built around the DOHaD paradigm that encompasses all aspects of environment. To better inform the global health efforts aimed at addressing the growing epidemic of chronic noncommunicable diseases of environmental origin, we propose a two-pronged approach: first, to make it clear that the current concept of DOHaD comprehensively includes a range of environmental factors and their relevance to disease occurrence not just throughout the life span but potentially across several generations; and second, to initiate the discussion of how adoption of DOHaD can promote a more realistic, accurate, and integrative approach to understanding environmental disruption of developmental programming and better inform clinical and policy interventions.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
Child Health Research Centre Publications
 
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