Formulation effects in percutaneous absorption

Kuswahyuning, Rina, Grice, Jeffery E., Moghimi, Hamid R. and Roberts, Michael S. (2015). Formulation effects in percutaneous absorption. In Nina Dragicevic and Howard I. Maibach (Ed.), Percutaneous penetration enhancers chemical methods in penetration enhancement : drug manipulation strategies and vehicle effects (pp. 109-134) Berlin / Heidelberg, Germany: Springer. doi:10.1007/978-3-662-45013-0_9

Author Kuswahyuning, Rina
Grice, Jeffery E.
Moghimi, Hamid R.
Roberts, Michael S.
Title of chapter Formulation effects in percutaneous absorption
Title of book Percutaneous penetration enhancers chemical methods in penetration enhancement : drug manipulation strategies and vehicle effects
Place of Publication Berlin / Heidelberg, Germany
Publisher Springer
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-662-45013-0_9
Open Access Status Not Open Access
Year available 2015
ISBN 9783662450130
Editor Nina Dragicevic
Howard I. Maibach
Chapter number 9
Start page 109
End page 134
Total pages 26
Total chapters 23
Collection year 2016
Language eng
Formatted Abstract/Summary
Formulation optimisation is one of the strategies used for optimising delivery into or through the skin. In addition to ensuring that an active chemical is delivered at an adequate rate to achieve therapeutic concentrations over the intended duration, physicochemical formulation stability as well as product acceptance must also be achieved. There is a continual growth in new potential delivery systems, such as microemulsions, liposomes, ultradeformable liposomes and lipid nanoparticles, offering various advantages, either for dermal and transdermal delivery. However, choosing and designing the most suitable formulation system for a given compound is a complex process. In this chapter, various aspects of formulation-related transdermal drug delivery are discussed and an alternative approach to the design of formulation systems is reviewed. In addition, current formulation-based strategies and the effects of commonly added ingredients for stability and aesthetic purposes are covered. Finally, formulations based on some novel delivery systems are discussed.
Keyword Skin
Transdermal drug delivery
Formulation optimisation
Formulation effects
Percutaneous absorption
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Non HERDC
School of Medicine Publications
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Created: Tue, 20 Oct 2015, 02:18:32 EST by System User on behalf of Medicine - Princess Alexandra Hospital