Gender Differences and Predictors of Mortality in Takotsubo Cardiomyopathy: Analysis from the National Inpatient Sample 2009-2010 Database

Krishnamoorthy, Parasuram, Garg, Jalaj, Sharma, Abhishek, Palaniswamy, Chandrasekar, Shah, Neeraj, Lanier, Gregg, Patel, Nainesh C., Lavie, Carl J. and Ahmad, Hasan (2015) Gender Differences and Predictors of Mortality in Takotsubo Cardiomyopathy: Analysis from the National Inpatient Sample 2009-2010 Database. Cardiology (Switzerland), 132 2: 131-136. doi:10.1159/000430782


Author Krishnamoorthy, Parasuram
Garg, Jalaj
Sharma, Abhishek
Palaniswamy, Chandrasekar
Shah, Neeraj
Lanier, Gregg
Patel, Nainesh C.
Lavie, Carl J.
Ahmad, Hasan
Title Gender Differences and Predictors of Mortality in Takotsubo Cardiomyopathy: Analysis from the National Inpatient Sample 2009-2010 Database
Journal name Cardiology (Switzerland)   Check publisher's open access policy
ISSN 1421-9751
0008-6312
Publication date 2015-07-07
Year available 2015
Sub-type Article (original research)
DOI 10.1159/000430782
Open Access Status Not Open Access
Volume 132
Issue 2
Start page 131
End page 136
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2016
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
2736 Pharmacology (medical)
Formatted abstract
Objectives: Takotsubo cardiomyopathy (TC) is characterized by left-ventricle apical ballooning with elevated cardiac biomarkers and electrocardiographic changes similar to an acute coronary syndrome. We studied the prevalence, in-hospital mortality, and predictors of mortality in TC. Methods: All patients ≥18 years of age diagnosed with TC were identified in the Nationwide Inpatient Sample (NIS) 2009-2010 database using the 9th revision of the International Classification of Diseases (ICD) 429.83. Demographics, conventional risk factors (diabetes, hypertension, hyperlipidemia, and tobacco abuse), acute critical illnesses like sepsis, acute cerebrovascular disease (cerebrovascular accident; CVA), acute respiratory insufficiency, and acute renal failure, and chronic conditions (anxiety, depression, and malignancy) were studied. Results: The prevalence of TC was 0.02% (n = 7,510). The total in-hospital mortality rate was 2.4%, with a higher mortality in men (4.8%) than in women (2.1%). Sepsis (9 vs. 4.2%; p < 0.01) was more prevalent in men with an increased prevalence of other critical illness, although this was not statistically significant. Age (OR 1.05; 95% CI 1.01-1.09), malignancy (OR 3.38; 95% CI 1.35-8.41), acute renal failure (OR 5.4; 95% CI 2.2-13.7), acute CVA (OR 9.4; 95% CI 2.96-29.8), and acute respiratory failure (OR 11.1; 95% CI 3.9-31.1) predicted mortality in fully adjusted models. Conclusion: A higher mortality was seen in men, likely related to the increased prevalence of acute critical illnesses, ventricular arrhythmia, and sudden cardiac arrest. Acute CVA and respiratory failure were the strongest predictors of mortality.
Keyword Takotsubo cardiomyopathy
Mortality
Acute critical illness
Gender differences
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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